Leoni and Duchovny got married on 6th May 1997, after only a short 8 weeks of dating and now have two children together; Madeline West and Kyd Miller.
Leoni once said 'the best thing about marriage is David's sense of humour,' (IMDB) something that she was also blessed with during their relationship; namely when Duchovny appeared on Who Wants To Be A Millionaire? and used his 'phone a friend' lifeline on her. When she couldn't answer the question she simply said, 'you're screwed honey!' (IMDB)
They had only one television appearance together where Leoni played herself in an episode of The X Files: Hollywood AD back in 2000.
On 29th August Duchovny checked himself into a rehabilitation facility for supposed sex addiction. Only two months later, it was announced that the couple had separated many months prior to this.
Duchovny allegedly planned to sue The Daily Mail for an article that was released saying that he had had an affair with Hungarian tennis instructor Edit Pakay while he was still married to Leoni. He denied the rumours and The Daily Mail retracted their story.
The pair got back together, however split in 2011 again and in 2013, Duchovny said that the couple were still married but separated. Their divorce was finalised in June 2014.
Source: Wikipedia and IMDB.