Georgia 'Toff' Toffolo and Stanley Johnson are to go on the run together.
The former 'I'm A Celebrity... Get Me Out Of Here!' campmates are joining forces in a bid to evade capture from a team of experts in the upcoming celebrity version of 'Hunted'.
Also taking part in this year's show to raise money for Stand Up To Cancer will be chefs Aldo Zilli and John-Christophe Novelli, rugby legends Gavin Henson and Martin Offiah and former 'Only Way is Essex' stars Lucy Mecklenburgh and Lydia Bright, who are both pregnant.
'Gogglebox' will also be back for a celebrity edition for the charity, though the stars taking part have yet to be announced, while Duncan James, AJ Odudu, Pete Wicks and Ulrika Jonsson will be among the famous faces looking for love with the aid of Fred Sirieix on 'Celebrity First Dates Hotel'.
Channel 4 bosses have promised the shows will all delight viewers, as well as making a lot of money for such a good cause.
Tom Beck, Head of Live Events and Commissioning Editor for Entertainment at Channel 4 said: "Every year we continue to be wowed by the amazing array of famous faces who give up their time so generously and of course the incredible public who campaign so fiercely and donate so much.
"We can't wait to see the celebrities in action, banging that Stand Up To Cancer drum - be it sitting on the sofa and watching telly, going on the run or hopefully finding love in the stunning Italian countryside."
This year's Stand Up To Cancer programming will also see Adam Hills, Alex Brooker and Josh Widdicombe kick off a new series of 'The Last Leg' with a special episode.
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