The rock duo is made up of guitarist Jack White and ex-wife drummer Meg White, and the former lovers will perform on the NBC talk show Late Night With Conan O'Brien on Friday 20 February.
In 2003, White Stripes performed a week-long residency on O'Brien's show, but on September 11, 2007, the duo were forced to cancel 18 tour dates in the US due to Meg suffering from acute anxiety problems. They also cancelled the their scheduled tour of the UK later that year.
The appeared together in public in June last year, when Meg ran onstage during a gig in their home town of Detroit, by Jack's other band The Raconteurs. She sat at the drum kit as Jack introduced her but she didn't play and ran off the stage again. Weird.
White Stripes first achieved commercial success with their fourth album, Elephant, in 2003 which topped the UK chart and spawned their breakthrough hit Seven Nation Army.