Madonna thinks that Kanye West is a "brilliant madman", but does admit he can sometimes be "inappropriate" with his opinions.
Speaking to the new issue of Rolling Stone magazine, she said of the musician: "He can't help himself. Like, he doesn't have the same filters other people have.
"He has to blurt things out, he's always saying inappropriate stuff. But he also has brilliant ideas, if you can get him to pay attention long enough, working with him in the studio."
And she admits that working with Kanye on her new album, as well as other collaborators, drove her "bonkers" because they sometimes lacked focus and were easily distracted.
"He would drive me bonkers, because he's got so many things going on in his life. And this seemed to be the theme of my record, working with people who can't get off their phone, can't stop tweeting, can't focus and finish a song. It drove me crazy. But when they did pay attention, it was brilliant. I was, like, running around with a butterfly net."
Last month Kanye went onto the stage at the Grammy Awards in a bid to interrupt Beck when he received the Album of the Year prize, but he was interrupted.
This was reminiscent of the time he jumped on stage to disrupt Taylor Swift during her acceptance speech for Video of the Year at the 2009 MTV Video Music Awards.
Madonna spoke of that incident, and said: "Don't go to awards shows looking for justice.
"That's like trying to find a needle in a haystack. Just go and have fun. I never got too engaged with who wins awards or not, because I don't honestly think it's that important.
"So that part of him I can't relate to. Like, what's the point of fighting for somebody to... like, 'This person should have got it?'...I think sometimes he takes things too seriously."
Whilst she doesn't always agree with Kanye's ways, she does think the rapper's good for the music industry.
"I feel like the music business needs him, because everyone's become so politically correct, so safe.
"I don't always agree with the things he says or does - I don't always like his music, even. But he's a beautiful mess. I love him."
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