Medicines
Our results show a potentially serious effect on mortality
Side effects of commonly used drugs appear to increase the risks of both cognitive impairment and death in older people.
The research carried out by the University of East Anglia is the first systematic investigation into the long term health impacts of 'antichlolinergic activity' - a know potenital side effect of many prescription and over the counter drugs. This affects the brain blocking a key neurotransmitter.
Medicines with some degree os anticholingergic effect are wide-ranging and many are frequently taken by older people. These the following groups with th egreatest impact, anti-depressants, tranquilisers, bladder medication, asthma treatment and epilepsy treatment.
Dr Chris Fox, clinical senior lecturer at Norwich Medical School, Univsersity of East Anglia, says: "This is the first large scale study into the long-term impact of medicines which block acetylcholine - a common brain neurotransmitter - on humas, and our results show a potentially serious effect on mortality."
He continues: "Further research must now be undertaken to understand possible reasons for this link and, in particular, whether and how the anticholinergic drugs might cause the increased mortality. In the meantime, I strongly advise patients with any concerns to continue taking their medicines until they have consulted their family doctor or their pharmacist.”
The study was launched as part of the drive to find ways of reducing risk factors for dementia which affects 820,000 people in the UK. More than 13,00 men and women aged 65 and over were included in the two-year study.
Dr Susanne Sorensen, head of research at the Alzheimer’s Society, says: “It is very important that we have a clear picture of the side effects of drugs commonly taken by older people with cognitive impairment and other conditions. This robust study provides valuable findings, and must be taken seriously. However it is vital that people do not panic or stop taking their medication without consulting their GP.
“We would urge people to have regular appointments with their doctor to review all drug treatments they are taking. This will help ensure they are on the best medications for their conditions, and that any side effects have been taken into consideration.”
Femalefirst Taryn Davies
Tagged in Health