Singer tweeted the clip to her followers this week which showed her in some of her trademark outfits. The clips alsoshows Maggie Simpson dressed up mimicing Gaga.
In the episode, Gaga comes to town on a train, complete with 18 separate outfits, to cheer up a depressed Lisa.
The singer made an unofficial cameo appearance on Family Guy last year, but this will be the first time she gives her voice to a cartoon.
The Simpsons which celebrates its 25th anniversary this year, has featured the likes of the Ramones, The White Stripes, Sonic Youth and the Red Hot Chili Peppers.
Lady Gaga is currently touring in Asia. The 'Born This Way Ball' comes to the UK later this year, starting at London's Twickenham Stadium.
Watch the teaser trailer of the episode on YouTube
http://www.youtube.com/watch?feature=player_embedded&v=yyxLrYnWcV4
Tagged in The Simpsons Lady GaGa