Following the murder of his adoptive father Nerio, Largo Winch (Tomer Sisley) is now CEO of the vast W Group.
But the compromises money and power require don't suit Largo. He announces the sale of the Group and the creation of a humanitarian foundation, to be led by his father's oldest friend.
The very day the agreement is signed Largo is accused of complicity in crimes against humanity.
International prosecutor Diane Franken (Sharon Stone) suspects him of having paid off - four years previously, for his father's benefit - notorious Burmese General Kyaw Min, after the displacement of a mineral-rich native village on behalf of the W Group turned into a massacre. And she has a witness.
The witness is no other than Malunaï, the beautiful Burmese villager with whom Largo had an intense love affair four years earlier.
Stunned, he determines to discover who is forcing Malunaï to lie, and to solve the mystery of his father's role in the atrocity. When he learns that Malunaï has been deported and is now in the hands of the General, Largo's convinced she will be killed.
He arrives in Burma with a highly dangerous plan and time running out. At Makiling Military Camp he will learn Malunaï's incredible secret. And discover that his enemies' plot is even more twisted than he imagined.
Based on the successful Belgian comic book series and novels by Philippe Francq and Jean Van Hamme, The Burma Conspiracy is the second film in the Largo Winch series, following Deadly Revenge which was released in 2010.