Madonna undergoes £250-a-session hand treatment to reduce wrinkles.
Madonna
The 57-year-old singer is often seen out and about with gloves on as a result of undergoing "redermalisation mesotherapy", but for the first time "in years" she has been able to step out without mittens on following a hat-trick of successful 45-minute procedures.
A source told the Daily Mirror newspaper: "Mesotherapy isn't too painful but nor is it for the faint-hearted.
"She has to wear gloves for 36 hours afterwards because hands come up in unsightly 'bubbles' of air as the amino acids and hyaluronic acid do their worst. Within three sessions, though, her hands were looking much better. She's thrilled with the results.
"She is now going out without gloves or mittens for the first time in years."
Popular in Russia, the treatment involves 80-100 tiny injections of pharmaceuticals and vitamins into the skin and has been dubbed "bubble therapy" as the skin comes up in micro-papules which is why Madonna has to wear gloves afterwards.
Iryna Stewart, who has practised mesotherapy for 10 years at her London clinic, added: "One treatment alone is like using a whole pot of expensive cream, but with instantaneous effects."
Madonna - who has kids, Lourdes, 19, and Rocco, 15, as well as 10-year-olds David and Mercy - is known for embracing her eye-catching style and is often seen in skimpy outfits onstage.
Lourdes recently praised her mother's fashion sense after making her modelling debut in a new campaign for Stella McCartney's latest fragrance, Pop.
She said: "My mom has helped me so much. She has great style and she's an amazing dresser."