Chelsea Handler's US talk show will end on August 26.
The 39 year old presenter, who confirmed in March she intended to leave 'Chelsea Lately' at the end of her contract, will depart E! three months before her current agreement comes to an end, and is delighted with the work she did for the network.
Chelsea said in a statement: "I myself am more surprised than anyone that I was able to hold down a job for seven years, and it was a fantastic seven years. I will always look back at my time on E! as most people look back at their time in college. I'm glad I went."
Suzanne Kolb, the president of E!, praised the star for adding "a distinct voice to late night with her acerbic wit and fearless commentary."
Until the station develops a possible replacement show, it will air E! News in the 11pm slot.
Chelsea, who is believed to have made around $9 million a year from the show, has previously voiced her concerns about the E! network and described it as "a sad, sad place to live."
She also said: "They don't know what they're doing. They have no ideas. It's a failure."
It is rumoured the comic will land a new contract with online streaming service Netflix.
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