Vaping raises the risk of heart failure.
A study in the US tracked 175,000 adults and discovered that those who used e-cigarettes were 19 per cent more likely to develop the life-threatening condition over the course of four years.
The increased danger was calculated once other factors that could cause the condition - such as whether participants smoked tobacco or were obese - were factored in.
Previous analysis suggests that vaping puts strain on the heart by increasing blood pressure and heart rate and the new study provides the clearest evidence yet of the dangers.
Dr. Yakubu Bene-Alhasan, lead author of the study at MedStar Health in Baltimore, said: "More and more studies are linking e-cigarettes to harmful effects and finding that it might not be as safe as previously thought.
"The difference we saw was substantial. It's worth considering the consequences to your health, especially with regard to heart health.
"I think this research is long overdue, especially considering how much e-cigarettes have gained traction."